脱氢紫堇碱 30045-16-0夏季促销2022  中文名称:去氢延胡索素中文同义词:脱氢紫堇碱;去氢延胡索素;脱氢紫堇碱,去氢紫堇碱、去氢延胡索甲素;去氢紫堇碱,去氢延胡索甲素,去氢延胡索素;脱氢紫堇碱(标准品);去氢紫堇碱、去氢延胡索甲素;脱氢紫堇碱(去氢紫堇碱,去氢延胡索甲素,去氢延胡索素);去氢紫堇碱(标准品)
英文名称:Dehydrocorydaline英文同义词:13-Methylpalmatine;dehydeocorydaline;Dehydrocorydaline;DEHYDROCORYDALINE98%;13-Methyl-2,3,9,10-tetramethoxy-5,6-dihydrodibenzo[a,g]quinolizinium;5,6-Dihydro-2,3,9,10-tetramethoxy-13-methyldibenzo[a,g]quinolizinium;Dibenzo[a,g]quinolizinium,5,6-dihydro-2,3,9,10-tetramethoxy-13-methyl-CAS号:30045-16-0
脱氢紫堇碱 30045-16-0夏季促销2022  分子式:C22H24NO4
分子量:0EINECS号:相关类别:中药对照品;标准品;植物提取物;植提标准品;对照品;标准品-中药标准品;chemicalreagent;pharmaceuticalintermediate;phytochemical;referencestandardsfromChinesemedicinalherbs(TCM).;standardizedherbalextract;生物碱;标准品-中药标准品;分析试剂-对照品;标准品，对照品Mol文件:30045-16-0.mol去氢延胡索素性质熔点170-173℃去氢延胡索素用途与合成方法生物活性Dehydrocorydaline(13-Methylpalmatine)是从中药延胡索Corydalisyanhusuo中分离得到的一种生物碱。Dehydrocorydaline调节BaxChemicalbook，Bcl-2蛋白表达；激活caspase-7，caspase-8，并使PARP失活。Dehydrocorydaline能增强p38MAPK活化，具有抗炎、抗癌等功效。
。Dehydrocorydaline具有强大的抗疟疾作用，并具低细胞毒性(细胞生存力>90％)，P.falciparum3D7strain(IC50=38nM)。靶点Bcl-2BaxCaspase-7Caspase-8PARP体外研究Dehydrocorydaline(0-200μM)treatmentsignificantlyinhibitsthegrowthofMCF-7cellsinadose-dependentmanner.Thecellviabilityisdecreasedbyapproximate40%after24hof200μMDehydrocorydaline.Dehydrocorydaline(0-200μM)dose-dependentlyincreasesBaxproteinexpressionanddecreasesBcl-2proteinexpression.Dehydrocorydaline(0-200μM)inducesactivationofcaspase-7,-8andthecleavageofPARPwithoutaffectingcaspase-9.体内研究DehydrocorydalinemanifestsalowacutetoxicitywithanLD50ofabout277.5±19.0mg/kgbodyweightinmicefollowingoraladministrationand21.1±1.4mg/kgforintraperitonealinjection.化学性质黄色针晶粉，可溶于甲醇、乙醇、DMSO等有机溶剂，来源于延胡索，元胡。用途脱氢紫堇碱具有镇痛、镇静的作用。用途用于含量测定/鉴定/药理实验等。药理药效:具有杀菌、消炎作用。

更新时间：2024/1/29 13:35:19