延胡索甲素,紫堇碱518-69-4   日热点中文名称:延胡索碱甲中文同义词:元胡提取物(延胡索延胡索碱);延胡索甲素(紫堇碱,延胡索碱,(+)-紫堇碱,D-紫堇碱,紫堇块茎碱);紫堇碱,延胡索碱,延胡索碱甲;(+)-CORYDALINE延胡索甲素;(十)一CORYDALINE;
元胡提取物;延胡索甲素(紫堇碱,延胡索碱,(+)-紫堇碱,D-紫堇碱);(+)-紫堇碱英文名称:Corydaline英
文同义词:[7S,13S,13aR,(+)]-5,8,13,13a-Tetrahydro-2,3,9,10-tetramethoxy-13-methyl-6H-dibenzo[a,g]quinolizine;d-Corydaline;2,3,9,10-TetraMethoxy-13-Methylberbine,8CI;CorydalisA;(13s-e)-thyl;2,3,9,10-tetramethoxy-13-alpha-methyl-13a-beta-berbin;2,3,9,10-tetramethoxy-13-methyl-berbin;6h-dibenzo(a,g)quinolizine,5,8,13,13a-tetrahydro-2,3,9,10-tetramethoxy-13-me
CAS号:518-69-4
 延胡索甲素,紫堇碱518-69-4   日热点分子式:C22H27NO4分子量:369.45EINECS号:相关类别:中草药成分;标准品-中药标准品;分析试剂标准品;标准品-对照品;对照品;中药对照品;Alkaloids;标准品;对照品,标准品;植物提取物;
chemicalreagent;pharmaceuticalintermediate;phytochemical;referencestandardsfromChinesemedicinalherbs(TCM).;standardizedherbalextract
;植提标准品;标准品-中药标准品;标准品，对照品Mol文件:518-69-4.mol延胡索碱甲性质熔点135°比旋光度D20+311°(c=0.8inalc)沸点499.57°C(roughestimate)密度1.1771(roughestimate)折射率1.5614(estimate)酸度系数(pKa)6.57±0.40(Predicted)InChIKeyVRSRXLJTYQVOHC-YEJXKQKISA-N延胡索碱甲用途与合成方法概述延胡索甲素为季胺类生物碱，是科紫堇属植物延胡索(CorydalisyanhusuoW.T.Wang)块茎中的主要有效成分。
 延胡索甲素,紫堇碱518-69-4   日热点
现代药理学表明延胡索甲素不仅有镇痛、兴奋子宫、抗心律失常等作用，延胡索甲素具有抗吗啡样作用，还可用于制备为戒毒药物。应用延胡索甲素在无毒性范围内能Chemicalbook够有效地抑制呼吸道病毒的复制，可进一步开发为治疗或预防病毒性呼吸道疾病的药物，具有广泛的应用景。生物活性Corydaline((+)-Corydaline)是一种从Corydalisyanhusuo提取的异喹啉生物碱，是一种AChE抑制剂，IC50为226µM。Corydaline是一种μ阿片受体(μ-opioidreceptor,Ki为1.23µM)激动剂，可抑制肠道病毒71(EV71)复制(IC50为25.23µM)。Corydaline具有抗血管生成，抗过敏，胃排空和抗伤害感受的作用。靶点IC50:226µM(AChE);25.23µM(Enterovirus71)Ki:1.23µM(μ-opioidreceptor)体外研究Corydaline(12.5-50µM;24hours)treatmentinhibitsEV71replicationbysuppressingtheCOX-2expressionandthephosphorylationofJNKMAPKandP38MAPKbutnotERKMAPKinvitro.CorydalinecouldinhibittheviralRNAsynthesisinadosedependentmanner.WesternBlotAnalysisCellLine:VerocellsinfectedwithEV71Concentration:12.5µM,25µM,50µMIncubationTime:24hoursResult:ReducedthephosphorylationofP38MAPKandJNKMAPKandtheexpressionofCOX-2.体内研究Corydaline(10mg/kg;subcutaneousadministration;once)treatmentshowsantinociceptiveeffectsinmicebysignificantlyinhibitingthewrithingbehavior.AnimalModel:MaleCD1mice(30-35g,7-8weeksold)injectedwithaceticacidDosage:10mg/kgAdministration:Subcutaneousadministration;onceResult:Showedantinociceptiveeffectsinmice.化学性质白色结晶粉末，可溶于甲醇、乙醇、DMSO等有机溶剂，来源于延胡索块茎，小泉紫堇全草，深山紫堇根，马尔查紫堇块茎和地上部分。用途延胡索甲素具有镇痛，镇静，催眠的作用。用途用于含量测定/鉴定/药理实验等。药理药效:镇痛作用。

更新时间：2024/1/29 13:35:19